Author

A. Carugo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Viale· 4 shared G. Genovese· 4 shared C. Zhu· 3 shared F. Carbone· 3 shared A. Futreal· 2 shared A. Sgambato· 2 shared C. A. Bristow· 2 shared E. Del Poggetto· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

A. Viale

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Author profile →

5 papers

Recent·Most cited

Evolutionary fingerprints of EMT in pancreatic cancers

L. Perelli, L. Zhang, S. Mangiameli, A. J. C. Russell, F. Giannese, F. Peng, F. Carbone, C. Le, H. Khan, F. Citron, M. Soeung, T. Lam, S. Lundgren, C. Zhu, D. Catania, , G. Genovese

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

bioRxiv · Sep 18, 2023 · PreprintCancer Biology

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

L. Yan, B. Tu, J. Yao, J. Gong, A. Carugo, C. Bristow, Q. Wang, C. Zhu, B. Dai, Y. Kang, L. Han, N. Feng, Y. Jin, J. Fleming, T. Heffernan, , H. Ying

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

bioRxiv · Jan 9, 2021Cancer Biology

9p21 Loss Defines the Evolutionary Patterns of Aggressive Renal Cell Carcinomas

F. Carbone, J. K. Huang, L. Perelli, E. Del Poggetto, T. Gutschner, H. Tomihara, M. Soeung, T. N. A. Lam, R. Xia, C. Zhu, X. Song, J. Zhang, K. Sircar, G. G. Malouf, A. Sgambato, , G. Genovese

This study establishes a mouse model of renal cell carcinoma showing that 9p21 loss drives aggressive tumor evolution with chromosomal instability and metastasis.

bioRxiv · Nov 3, 2020 · PreprintCancer Biology

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

F. Puca, F. Yu, C. Bertolacci, P. Pettazzoni, A. Carugo, E. Huang-Hobbs, J. Liu, C. Zanca, F. Carbone, E. Del Poggetto, J. Gumin, P. Dasgupta, S. Seth, F. F. Lang, E. Sulman, , G. Draetta

This study identifies MCAD as a critical enzyme for fatty acid metabolism in GBM, showing its essential role in preventing mitochondrial damage and apoptosis.

bioRxiv · Sep 28, 2020 · PreprintCancer Biology

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

J. L. Rose, S. Srinivasan, W. Yao, S. Seth, M. Peoples, A. Machado, C.-Y. Li, I. L. Ho, J. J. Lee, P. A. Guerrero, E. Kim, M. Syed, J. R. Daniele, A. Deem, M. Kim, , G. F. Draetta

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

bioRxiv · Sep 17, 2020 · PreprintCancer Biology