Endosomal Trafficking of Two Pore K+ Efflux Channel TWIK2 to Plasmalemma Mediates NLRP3 Inflammasome Activation and Inflammatory Injury
A. Di, L. S. Huang, B. Zhou, P. T. Toth, Y. Krishnan, A. B. Malik
This study shows that TWIK2 channels are trafficked from endosomes to the plasma membrane via Rab11a in response to ATP, leading to K+ efflux and NLRP3 inflammasome activation, which can be inhibited to reduce inflammation.
bioRxiv · Oct 12, 2022Cell Biology