Y. Krishnan

TMEM165 acts as a proton-activated Ca2+ importer in lysosomes

The paper identifies TMEM165 as a proton-activated Ca2+ importer in lysosomes, revealing a new mechanism for lysosomal Ca2+ refilling.

SLC12A9 is a lysosome-detoxifying ammonium - chloride co-transporter

This study identifies SLC12A9 as a lysosomal ammonium exporter that maintains lysosomal homeostasis by transporting ammonium and chloride.

Passive endocytosis in model protocells

This study shows that model protocells can perform a process similar to passive endocytosis, allowing rapid uptake and slow release of impermeable molecules, suggesting a possible mechanism for early nutrient acquisition before protein transporters evolved.

Endosomal Trafficking of Two Pore K+ Efflux Channel TWIK2 to Plasmalemma Mediates NLRP3 Inflammasome Activation and Inflammatory Injury

This study shows that TWIK2 channels are trafficked from endosomes to the plasma membrane via Rab11a in response to ATP, leading to K+ efflux and NLRP3 inflammasome activation, which can be inhibited to reduce inflammation.

Tissue specific targeting of DNA nanodevices in a multicellular living organism

This study demonstrates the targeting of DNA nanodevices to specific cell types in C. elegans using receptor-ligand interactions and biological barriers.

Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis

This study identifies tubular lysosomes in macrophages as having ion gradients that prepare them for phagocytosis without activating the cells.

A DNA-based voltmeter for organelles

A DNA-based voltmeter measures membrane potential of specific organelles in live cells, enabling non-invasive quantification previously unattainable.

High lumenal chloride in the lysosome is critical for lysosome function.

The paper measures lysosomal chloride levels in multiple models and finds that chloride reduction impairs lysosomal function.