Z. Wei

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

PerturBase: a comprehensive database for single-cell perturbation data analysis and visualization

PerturBase is a database that compiles and visualizes single-cell perturbation data from multiple studies, enabling analysis of genetic and chemical perturbations across millions of cells.

LRG1 promotes atherosclerosis by activating macrophages

This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.

Nuclear cytoophidia assembly represses transcriptional activity to control skeletal development and homeostasis

This study identifies nuclear cytoophidia as regulators of Impdh2 transcriptional activity, impacting skeletal development and homeostasis through effects on endochondral ossification and osteoclast function.

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

Long-Term In Vivo Molecular Monitoring Using Aptamer-Graphene Microtransistors

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

SIDERITE: Unveiling Hidden Siderophore Diversity in the Chemical Space Through Digital Exploration

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

Biodecomposing Spirulina platensis by a de novo designed Bacillus subtilis-based method to develop a medium for the high cell-density cultivation of Escherichia coli in batch mode

This paper develops a method to biodecompose Spirulina platensis using Bacillus subtilis to create a medium for high cell-density cultivation of Escherichia coli, achieving higher growth rates and optical density than traditional LB broth.

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis

This study compares the tumorigenic potential of MOLT4 and JURKAT T-ALL cell lines, finding that CCR9 overexpression enhances cholesterol biosynthesis and promotes T-ALL progression.

A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

This study examines the effects of six pyrimidine analogs on Tetrahymena thermophila growth and their mechanisms of action, finding that different analogs inhibit growth through distinct sites and that some effects are reversible with specific nucleobases or nucleosides.

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

This study identifies the role of phospholipid remodeling and PUFA uptake via CD36 in megakaryopoiesis and platelet production, showing dietary fatty acids impact platelet counts.

Targeting GDF15 as a potential therapy for low back pain originating from endplate

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

Three-dimensional structured illumination microscopy with enhanced axial resolution

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

The splicing isoform Foxpdelta2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasis

This study shows that the Foxp3{Delta}2 isoform, generated by alternative splicing, alters Treg function by enhancing DNA binding and affecting homeostasis in different Treg subsets.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

A Self-Healing, Viscoelastic Hydrogel Promotes Healing of Brain Lesions

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

Engineering ecologically complementary rhizosphere probiotics using consortia of specialized bacterial mutants

This study improves plant growth-promotion by engineering specialized bacterial mutants within a single species and assembling them into consortia that enhance root colonization and disease resistance.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Introduction of probiotic bacterial consortia promotes plant growth via impacts on the resident rhizosphere microbiome

This study shows that introducing probiotic bacterial consortia to tomato plants enhances growth by increasing rhizosphere microbiome diversity and abundance of rare taxa, rather than directly adding beneficial traits.

Epigallocatechin Gallate from Green Tea Effectively Blocks Infection of SARS-CoV-2 and New Variants by Inhibiting Spike Binding to ACE2 Receptor

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

An uncanonical transcription factor-DREB2B regulates seed vigor negatively through ABA pathway

This study identifies DREB2B as a negative regulator of seed vigor through the ABA pathway in Arabidopsis and cotton, interacting with RCD1 and synergizing with ABI3.

Continuous cis-regulatory changes in an advantageous gene are linked with adaptive radiation in cichlid fishes

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

Increased light availability enhances tolerance against ocean acidification stress in Halimeda opuntia

Increased light availability enhances stress resistance in Halimeda opuntia by the accumulation of soluble organic molecules and enzyme-driven activities to alleviate ocean acidification stress.

lncRNA-RMST functioned as a SOX2 transcription co-regulator to regulate miR-1251 in the progression of Hirschsprung's disease

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

Short-chain fatty acid production by gut microbiota from children with obesity is linked to bacterial community composition and prebiotic choice

This study examines SCFA production by gut microbiota from children with obesity in response to different prebiotics, finding significant inter-donor variation and donor-dependent effectiveness.

Bedscales: A non-contact adherence-independent multi-person sensor for longitudinal physiologic monitoring in the home bed

Bedscales is a non-contact sensor placed under a bed that monitors physiologic data without patient adherence, showing potential for chronic disease monitoring and hospitalization prediction.