Author

A. Dorhoi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Organism:rat· 2 Assay:organoid / primary culture· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

D. Hoffmann· 4 shared M. Beer· 4 shared B. Corleis· 3 shared C. Fricke· 3 shared K. Wernike· 3 shared L. Ulrich· 3 shared N. J. Halwe· 3 shared N. Roth· 3 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

D. Hoffmann

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reconstructing bat antiviral immunity using epithelial organoids

M. J. Kellner, P. Zelger, V. Monteil, G. Pei, M. Onji, K. Nayak, M. Zilbauer, A. Balkema-Buschmann, A. Dorhoi, A. Mirazimi, J. M. Penninger

This study uses bat epithelial organoids to investigate antiviral immunity differences between bats and humans, revealing unique interferon responses and implications for viral pathogenesis.

bioRxiv · Apr 5, 2024 · PreprintImmunology

Assessment of Immunogenicity and Efficacy of CV0501 mRNA-based Omicron COVID-19 Vaccination in Small Animal Models

N. Roth, J. Gergen, K. Kovacikova, S. Mueller, L. Ulrich, J. Schoen, N. J. Halwe, C. Fricke, B. Corleis, A. Dorhoi, D. Hoffmann, M. Beer, D. Maione, B. W. Petsch, S. Rauch

This paper evaluates the immunogenicity and efficacy of a bivalent mRNA vaccine CV0501 against Omicron subvariants in animal models, showing robust neutralizing antibodies and reduced viral loads.

bioRxiv · Jan 4, 2023Immunology

Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model

B. Corleis, D. Hoffmann, S. Rauch, C. Fricke, N. Roth, J. Gergen, K. Kovacikova, K. Schlottau, N. J. Halwe, L. Ulrich, J. Schön, K. Wernike, M. Widera, S. Ciesek, S. O. Mueller, , A. Dorhoi

This study shows a low-dose bivalent mRNA vaccine targeting multiple SARS-CoV-2 variants provides strong protection in mice and rats, with comparable antibody levels and reduced viral replication.

bioRxiv · Apr 20, 2022 · PreprintImmunology

CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

D. Hoffmann, B. Corleis, S. Rauch, N. Roth, J. Muehe, N. J. Halwe, L. Ulrich, C. Fricke, J. Schoen, A. Kraft, A. Breithaupt, K. Wernike, A. Michelitsch, F. Sick, C. Wylezich, , M. Beer

This study evaluates the efficacy of the CVnCoV mRNA vaccine against ancestral and emerging SARS-CoV-2 variants in a human ACE2 transgenic mouse model, showing complete protection against B.1.351.

bioRxiv · Mar 22, 2021Microbiology

Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection

C. M. Freuling, A. Breithaupt, T. Mueller, J. Sehl, A. Balkema-Buschmann, M. Rissmann, A. Klein, C. Wylezich, D. Hoeper, K. Wernike, A. Aebischer, D. Hoffmann, V. Friedrichs, A. Dorhoi, M. Groschup, , T. C. Mettenleiter

This study shows raccoon dogs are susceptible to SARS-CoV-2 infection and can transmit it to direct contact animals, suggesting they may act as intermediate hosts.

bioRxiv · Aug 19, 2020Microbiology