Author
T. C. Mettenleiter
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2023 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 38 mutual co-author links13 papers
Recent·Most cited
- MicrobiologybioRxiv
NECing goes: flexibility of the herpesvirus nuclear egress complex
V. Prazak, Y. Mironova, D. Vasishtan…·K. Grünewald
This study examines the structure and flexibility of the herpesvirus nuclear egress complex (NEC) using electron cryo-tomography, revealing its hexameric lattice and role in capsid envelopment.
DOI 10.1038/s41564-024-01716-8 - ImmunologybioRxiv
Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs
O. Bagato, A. Balkema-Buschmann, D. Todt…·D. S. Ushakov
This study uses 3D spatiotemporal analysis to show that SARS-CoV-2 infection in hamsters leads to monocyte-derived macrophage infiltration, vascular damage, and virus clearance, followed by tissue remodeling and fibrosis.
DOI 10.1128/spectrum.02469-23 - MicrobiologybioRxiv
CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with The VPS39 Subunit of HOPS Complex and Promotes Lysosome Clustering
K. M. Dolata, W. Fuchs, G. Caignard…·A. Karger
This study identifies CP204L as an ASFV protein that interacts with VPS39, altering lysosome dynamics and promoting virus replication.
DOI 10.1128/jvi.01943-22 - ImmunologybioRxivPreprint
Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model
B. Corleis, D. Hoffmann, S. Rauch…·A. Dorhoi
This study shows a low-dose bivalent mRNA vaccine targeting multiple SARS-CoV-2 variants provides strong protection in mice and rats, with comparable antibody levels and reduced viral replication.
- MicrobiologybioRxiv
Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic
C. Blaurock, A. Breithaupt, S. Weber…·A. Balkema-Buschmann
This study determines the minimum infective dose of SARS-CoV-2 for Golden Syrian hamsters and highlights their high susceptibility, suggesting a potential zoonotic risk.
DOI 10.1038/s41598-022-19222-4 - MicrobiologybioRxiv
Serological screening in wild ruminants in Germany, 2021/22: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus
K. Wernike, L. Fischer, M. Holsteg…·M. Beer
The paper serologically screens wild ruminants in Germany for SARS-CoV-2, bluetongue virus, pestivirus, and Schmallenberg virus, finding no evidence of spread but high seroprevalence against Schmallenberg virus and potential cross-reactivity with SARS-CoV-2.
DOI 10.1111/tbed.14600 - MicrobiologybioRxiv
CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
D. Hoffmann, B. Corleis, S. Rauch…·M. Beer
This study evaluates the efficacy of the CVnCoV mRNA vaccine against ancestral and emerging SARS-CoV-2 variants in a human ACE2 transgenic mouse model, showing complete protection against B.1.351.
DOI 10.1038/s41467-021-24339-7 - MicrobiologybioRxiv
Preferential selection and contribution of non-structural protein 1 (NS1) to the efficient transmission of the panzootic avian influenza H5N8 2.3.4.4 clades A and B viruses in chickens and ducks
C. Blaurock, A. Breithaupt, D. Scheibner…·E. M. Abdelwhab
This study identifies NS1 protein length variations in H5N8 avian influenza viruses that affect their transmission and virulence in chickens and ducks.
DOI 10.1128/jvi.00445-21 - MicrobiologybioRxiv
3D reconstruction of SARS-CoV-2 infection in ferrets emphasizes focal infection pattern in the upper respiratory tract
L. M. Zaeck, D. Scheibner, J. Sehl…·S. Finke
This study uses 3D imaging to show SARS-CoV-2 preferentially infects the upper respiratory tract of ferrets with a focal pattern in nasal turbinates.
DOI 10.3390/v13030529 - MicrobiologybioRxiv
Experimental infection of cattle with SARS-CoV-2
L. Ulrich, K. Wernike, D. Hoffmann…·M. Beer
This study infects cattle with SARS-CoV-2 and observes limited replication and sero-reactivity in some animals while in-contact animals remain uninfected.
DOI 10.3201/eid2612.203799 - MicrobiologybioRxiv
Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection
C. M. Freuling, A. Breithaupt, T. Mueller…·T. C. Mettenleiter
This study shows raccoon dogs are susceptible to SARS-CoV-2 infection and can transmit it to direct contact animals, suggesting they may act as intermediate hosts.
DOI 10.3201/eid2612.203733 - MicrobiologybioRxiv
Pitfalls in SARS-CoV-2 PCR diagnostics
K. Wernike, M. Keller, F. J. Conraths…·M. Beer
This study identifies contamination of commercial PCR reagents as a source of false positives in SARS-CoV-2 testing, emphasizing the need for rigorous validation of reagents before use.
DOI 10.1111/tbed.13684