A. Klein

Evolving properties of biological materials captured via needle-based cavity expansion method

This study uses VCCE to measure time-dependent mechanical changes in liver and gelatin, showing stiffening with age and demonstrating VCCE's precision in capturing these variations.

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

This study investigates how SARS-CoV-2 peptides form amyloid assemblies with varying neurotoxicity and polymorphic structures, showing that aggregation conditions influence toxicity and cellular uptake.

Protein deuteration via algal amino acids to overcome proton back-exchange for fast-MAS solid-state NMR of large proteins

The paper demonstrates that deuteration via deuterated amino acids improves spectral resolution for large proteins in solid-state NMR by avoiding proton back-exchange issues.

Cross-species comparison of pregnancy-induced GDF15

This study compares GDF15 expression during pregnancy across species, finding significant differences in plasma levels and expression between humans/macacaques and rodents.

Integrated assessment of structure and dynamics of solid proteins via accurate solid-state NMR distance information

The paper provides accurate solid-state NMR distance information for solid proteins, enabling high-resolution structural analysis and molecular dynamics simulations of conformational dynamics.

Characterisation of TbSmee1 indicates that endocytosis is required for access of surface-bound cargo to the trypanosome flagellar pocket

This study characterizes TbSmee1 in Trypanosoma brucei, showing that endocytosis is required for surface-bound cargo to access the flagellar pocket.

Dynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

This study tests the relationship between microbial uptake of low-molecular-weight organic substrates and their oxidation state using three soil microorganisms, finding weak or no predictive power of oxidation state for substrate utilization and efficiency.

Comparative Pathogenesis of Different Phylogroup I Bat Lyssaviruses in a Standardized Mouse Model

This study compares the pathogenicity and virus shedding of 13 lyssavirus isolates in a mouse model, revealing differences in clinical signs, survival, and astrocyte infection.

Spatiotemporal Dynamics of Stemphylium Leaf Blight and Potential Inoculum Sources in New York Onion Fields

This study investigates the spatiotemporal dynamics of Stemphylium leaf blight in New York onion fields and evaluates potential inoculum sources, finding that external inoculum may limit the effectiveness of in-field management.

The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle

This study shows that Prox1 gene transfer reduces muscle fragility in exercised dystrophic mdx mice but not sedentary ones, suggesting a synergistic effect with chronic exercise.

Residue-specific insights into (2x)72 kDa tryptophan synthase obtained from fast-MAS 1H-detected solid-state NMR

This study uses solid-state NMR to characterize a 72 kDa tryptophan synthase, overcoming size limitations and providing insights into catalytic residues.

Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection

This study shows raccoon dogs are susceptible to SARS-CoV-2 infection and can transmit it to direct contact animals, suggesting they may act as intermediate hosts.

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma

This study shows that laminin α1 promotes colon tumor growth by facilitating VEGFA-driven angiogenesis through interactions with integrin β1 and CXCR4.