Author

A. E. Murmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. E. Peter· 6 shared E. T. Bartom· 4 shared M. Patel· 4 shared C. Law· 3 shared Q. Q. Gao· 3 shared S. Chen· 3 shared A. A. Sarshad· 2 shared A. Haluck-Kangas· 2 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersCancer Biology

M. E. Peter

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Tumor expressed CD95 causes suppression of anti-tumor activity of NK cells in a model of triple negative breast cancer

A. S. Qadir, J. P. Guegan, C. Ginestier, A. Chaibi, A. Bessede, E. Charafe-Jauffret, M. Macario, V. Lavoue, T. de la Motte Rouge, C. Law, J. Vilker, H. Wang, E. Stroup, M. J. Schipma, B. Bridgeman, , M. E. Peter

This study shows that CD95 expression by tumor cells suppresses NK cell anti-tumor activity in triple negative breast cancer, leading to reduced tumor growth in immune-competent mice.

bioRxiv · Feb 12, 2021Cancer Biology

Identification of the toxic 6mer seed consensus in human cancer cells

M. Patel, E. T. Bartom, B. Paudel, M. Kocherginsky, K. L. O'Shea, A. E. Murmann, M. E. Peter

The paper identifies GGGGGC as the most toxic 6mer seed in human cancer cells, confirming its mechanism through targeted gene disruption and reporter assays.

bioRxiv · Dec 22, 2020Cancer Biology

6mer seed toxicity in viral microRNAs

A. E. Murmann, E. T. Bartom, M. J. Schipma, J. Vilker, S. Chen, M. E. Peter

The paper identifies 6mer seed toxicity in viral miRNAs, showing some v-miRNAs kill cells via G-rich 6mer sequences, unlike most cellular miRNAs.

bioRxiv · Nov 12, 2019Cell Biology

6mer seed toxicity in tumor suppressive microRNAs

Q. Q. Gao, W. E. Putzbach, A. E. Murmann, S. Chen, A. A. Sarshad, J. M. Peter, E. T. Bartom, M. Hafner, M. E. Peter

The paper identifies 6mer seed sequences in miRNAs that are toxic to cancer cells, showing that tumor suppressive miRNAs use these toxic seeds to kill cancer cells.

bioRxiv · Aug 31, 2018Cell Biology

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

A. E. Murmann, Q. Q. Gao, W. Putzbach, M. Patel, E. T. Bartom, C. Law, B. Bridgeman, S. Chen, K. M. McMahon, C. S. Thaxton, M. E. Peter

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.

bioRxiv · Jan 12, 2018Cancer Biology

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

W. Putzbach, Q. Q. Gao, M. Patel, S. van Dongen, A. Haluck-Kangas, A. A. Sarshad, E. Bartom, K.-Y. A. Kim, D. M. Scholtens, M. Hafner, J. C. Zhao, A. E. Murmann, M. E. Peter

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

bioRxiv · Sep 14, 2017Cancer Biology

Induction of DISE in ovarian cancer cells in vivo

A. E. Murmann, K. M. McMahon, A. Haluck-Kangas, N. Ravindran, M. Patel, C. Law, S. Brockway, J.-J. Wei, C. S. Thaxton, M. Peter

This study shows that DISE can be induced in ovarian cancer cells in vivo using siRNA-TLPs, leading to tumor growth reduction.

bioRxiv · Sep 10, 2017Cancer Biology