Author

W. Putzbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

M. E. Peter· 3 shared Q. Q. Gao· 3 shared A. A. Sarshad· 2 shared A. E. Murmann· 2 shared A. Haluck-Kangas· 2 shared E. T. Bartom· 2 shared M. Hafner· 2 shared M. Patel· 2 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

M. E. Peter

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Author profile →

4 papers

Recent·Most cited

Cell autonomous versus systemic Akt isoform deletions uncovered new roles for Akt1 and Akt2 in breast cancer

N. Hay, X. Chen, M. M. Ariss, G. Ramakrishnan, V. Nogueira, C. Blaha, W. Putzbach, A. B. M. M. K. Islam, M. V. Frolov

The paper compares cell autonomous and systemic Akt1/Akt2 deletion effects in breast cancer, finding distinct roles in tumorigenesis and metastasis.

bioRxiv · Jan 8, 2020Cancer Biology

CD95/Fas ligand mRNA is toxic to cells

W. Putzbach, A. Haluck-Kangas, Q. Q. Gao, A. A. Sarshad, E. T. Bartom, A. M. Stults, A. S. Qadir, M. Hafner, M. E. Peter

The paper shows that full-length CD95L mRNA is toxic to cells and induces apoptosis through sRNA processing independent of Dicer and Drosha, suggesting a new role for RNAi in cell fate regulation.

bioRxiv · Sep 14, 2018Cancer Biology

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

A. E. Murmann, Q. Q. Gao, W. Putzbach, M. Patel, E. T. Bartom, C. Law, B. Bridgeman, S. Chen, K. M. McMahon, C. S. Thaxton, M. E. Peter

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.

bioRxiv · Jan 12, 2018Cancer Biology

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

W. Putzbach, Q. Q. Gao, M. Patel, S. van Dongen, A. Haluck-Kangas, A. A. Sarshad, E. Bartom, K.-Y. A. Kim, D. M. Scholtens, M. Hafner, J. C. Zhao, A. E. Murmann, M. E. Peter

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

bioRxiv · Sep 14, 2017Cancer Biology