Heme induces innate immunity memory
E. Jentho, B. Novakovic, C. C. Ruiz-Moreno, I. Kourtzelis, R. Martins, T. Chavakis, M. P. Soares, L. Kalafati, J. Guerra, F. Roestel, P. Bohm, M. Godmann, T. Grinenko, A. Eugster, M. Beretta, , S. Weis
This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.
bioRxiv · Dec 12, 2019 · PreprintImmunology