Author

T. Chavakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 9 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Assay:metabolomics· 3 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

B. Wielockx· 5 shared A. Palladini· 3 shared A. Sinha· 3 shared I. Kourtzelis· 3 shared T. Grinenko· 3 shared U. Coskun· 3 shared V. I. Alexaki· 3 shared A. Dahl· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersCell Biology

B. Wielockx

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

J. Lukaszonek, N. Brown, J. Zenga, E. Myburgh, J. P. Hewitson, G. Hajishengalis, T. Chavakis, P. M. Kaye, I. Kourtzelis

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

bioRxiv · Apr 24, 2024 · PreprintImmunology

CD38 promotes hematopoietic stem cell dormancy via c-Fos

L. Ibneeva, S. P. Singh, A. Sinha, S. E. Eski, R. Wehner, L. Rupp, J. A. Perez-Valencia, A. Gerbaulet, S. Reinhardt, M. Wobus, M. Bonin, J. Sancho, F. E. Lund, A. Dahl, M. Schmitz, , T. Grinenko

This study identifies CD38 as a marker for dormant hematopoietic stem cells and shows it promotes dormancy through the cADPR/Ca2+/c-Fos/p57Kip2 pathway.

bioRxiv · Feb 8, 2023 · PreprintCell Biology

Succinate mediates inflammation-induced adrenocortical dysfunction

I. Mateska, A. Witt, E. Hagag, A. Sinha, C. Yilmaz, E. Thanou, N. Sun, O. Kolliniati, M. Patschin, H. Abdelmegeed, H. Henneicke, W. Kanczkowski, B. Wielockx, C. Tsatsanis, A. Dahl, , V. I. Alexaki

This study identifies the IL-1β-DNMT1-SDHB-succinate axis as a mechanism by which inflammation impairs adrenal steroidogenesis.

bioRxiv · Apr 29, 2022Immunology

Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

M. GOMEZ SALAZAR, I. PRUNONOSA CERVERA, R. WANG, K. FRENCH, R. GARCIA-MARTIN, M. BLÜHER, C. J. SCHOFIELD, R. H. STIMSON, T. CHAVAKIS, E. F. GUDMUNDSSON, L. L. JENNINGS, V. G. GUDNASON, N. M. MORTON, V. EMILSSON, Z. MICHAILIDOU

This study shows that deleting PHD2 in adipocytes maintains BAT activity at thermoneutrality, increases energy expenditure, and identifies serum PHD2 as a biomarker for metabolic disease.

bioRxiv · Jan 5, 2021 · PreprintPhysiology

Obesity-associated lipidomic remodeling of the adrenal gland indicates an important role of the FADS2-arachidonic acid axis in adrenocortical hormone production

A. Witt, P. Mirtschink, A. Palladini, I. Mateska, H. Abdelmegeed, M. Grzybek, B. Wielockx, M. Peitzsch, U. Coskun, T. Chavakis, V. I. Alexaki

This study identifies obesity-induced lipidomic changes in the adrenal gland, showing that the FADS2-arachidonic acid pathway regulates adrenocortical hormone production.

bioRxiv · Sep 4, 2020 · PreprintCell Biology

HIF2α is a Direct Regulator of Neutrophil Motility

S. Sormendi, M. Deygas, A. Sinha, A. Krueger, I. Kourtzelis, G. Le Lay, M. Bernard, P. Saez, M. Gerlach, K. Franke, A. Meneses, M. Kraeter, A. Palladini, J. Guck, U. Coskun, , B. Wielockx

This study identifies HIF2α as a regulator of neutrophil motility through the PHD2-HIF2-RhoA axis, enhancing migration in hypoxic environments during inflammation.

bioRxiv · Jun 5, 2020Immunology

Heme induces innate immunity memory

E. Jentho, B. Novakovic, C. C. Ruiz-Moreno, I. Kourtzelis, R. Martins, T. Chavakis, M. P. Soares, L. Kalafati, J. Guerra, F. Roestel, P. Bohm, M. Godmann, T. Grinenko, A. Eugster, M. Beretta, , S. Weis

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.

bioRxiv · Dec 12, 2019 · PreprintImmunology

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

M. Grzybek, A. Palladini, V. I. Alexaki, M. A. Surma, K. Simons, T. Chavakis, C. Klose, U. Coskun

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.

bioRxiv · Nov 14, 2018 · PreprintPhysiology

Hematopoietic stem cells differentiate into restricted myeloid progenitors before cell division

T. Grinenko, A. Eugster, L. Thielecke, B. Ramasz, A. Krueger, S. Dietz, I. Glauche, A. Gerbaulet, M. von Bonin, O. Basak, H. Clevers, T. Chavakis, B. Wielockx

This study shows hematopoietic stem cells can differentiate into restricted progenitors without dividing or entering the S phase, indicating fate decisions are uncoupled from cell division.

bioRxiv · Jan 30, 2018Cell Biology