Author

A. Farhat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. S. Biteen· 2 shared K. Ragunathan· 2 shared S. Biswas· 2 shared Z. Chen· 2 shared A. Alimohammadi· 1 shared A. Hladik· 1 shared A. Korosec· 1 shared A. Levashkevich· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

J. S. Biteen

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4 papers

Recent·Most cited

Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions

Z. Chen, M. Seman, A. Farhat, Y. Fyodorova, S. Biswas, A. Levashkevich, L. P. Freddolino, J. S. Biteen, K. Ragunathan

The paper uses live-cell single-molecule tracking to study how H3K9me affects HP1 protein interactions in fission yeast.

bioRxiv · Mar 8, 2023Biophysics

A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4

R. Gawish, B. Maier, G. Obermayer, M. Watzenboeck, A.-D. Gorki, F. Quattrone, A. Farhat, K. Lakovits, A. Hladik, A. Korosec, A. Alimohammadi, I. Mesteri, F. Oberndorfer, F. Oakley, J. Brain, , S. Knapp

This study identifies a neutrophil-B-cell axis that promotes disease tolerance during sepsis through Cxcr4 activation, reducing organ damage and immunothrombosis.

bioRxiv · Mar 21, 2022Immunology

A subset of gut leukocytes have telomerase-dependent 'hyper-long' telomeres and require telomerase for function in zebrafish

P. S. Ellis, R. R. Martins, E. Thompson, A. Farhat, S. A. Renshaw, C. M. Henriques

This paper shows that telomerase-dependent 'hyper-long' telomeres in zebrafish gut macrophages and dendritic cells decline with age, leading to impaired immunity and increased gut permeability.

bioRxiv · Jan 31, 2022Cell Biology

HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization

S. Biswas, J. Karslake, Z. Chen, A. Farhat, P. Freddolino, J. S. Biteen, K. Ragunathan

This study investigates how HP1 proteins recognize H3K9me with high specificity despite low-affinity binding, showing that oligomerization compensates for this and enables heterochromatin localization.

bioRxiv · Jan 26, 2021Biophysics