P. Freddolino

Intracellular acidification is a hallmark of thymineless death in E. coli

The paper identifies intracellular acidification as a key causal factor in thymineless death in E. coli, showing it reduces cell viability when pH is increased.

Epistasis at the SARS-CoV-2 RBD Interface and the Propitiously Boring Implications for Vaccine Escape

This study analyzes epistatic interactions among RBD mutations in SARS-CoV-2 variants to assess their impact on vaccine escape potential.

Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection

The paper investigates how a dominant-negative variant of TNFRSF13B confers resistance to enteric pathogens by reducing natural IgA, suggesting balancing selection due to its dual role in immunity and pathogenesis.

HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization

This study investigates how HP1 proteins recognize H3K9me with high specificity despite low-affinity binding, showing that oligomerization compensates for this and enables heterochromatin localization.

Escherichia coli Lrp regulates one-third of the genome via direct, cooperative, and indirect routes

This study identifies 35% of E. coli genes regulated by Lrp through ChIP-seq and RNA sequencing under nine conditions, revealing new binding patterns and regulatory mechanisms.