Restrained activation of CYFIP2-containing WAVE complexes controls membrane protrusions and cell migration
A. Polesskaya, A. Boutillon, S. Yang, Y. Wang, S. Romero, Y. Liu, M. Lavielle, N. Molinie, N. Rocques, A. Fokin, R. Guerois, B. Chen, N. B. David, A. M. Gautreau
The paper shows CYFIP2-containing WAVE complexes restrain RAC1 activation, affecting cell migration, and mutations in CYFIP2 can enhance its activity.
bioRxiv · Jul 2, 2020 · PreprintCell Biology