Cancer BiologyFrontiers in OncologyPeer-reviewed
Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription
E. Arnaiz, A. Miar, A. G. Dias…·A. L. Harris
The paper shows hypoxia reduces mitochondrial double-stranded RNA production in breast cancer cells, leading to decreased type I IFN signaling and immunosuppression.
DOI 10.3389/fonc.2021.779739