Author

D. Waithe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:cell signaling & trafficking· 5 Assay:fluorescence / live-cell microscopy· 5 Approach:experimental assay· 4 Organism:human· 4 Approach:microscopy & imaging analysis· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

C. Eggeling· 6 shared E. Sezgin· 3 shared F. Schneider· 3 shared K. Reglinski· 3 shared I. Urbancic· 2 shared J. Sehr· 2 shared P. Carravilla· 2 shared P. Hublitz· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersBiophysics

C. Eggeling

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Author profile →

10 papers

Recent·Most cited

Neural Network Informed Photon Filtering Reduces Artifacts in Fluorescence Correlation Spectroscopy Data

A. Seltmann, P. Carravilla, K. Reglinski, C. Eggeling, D. Waithe

This paper introduces a neural network to filter artifacts in fluorescence correlation spectroscopy data, improving analysis of samples with peak artifacts.

bioRxiv · Aug 24, 2023Biophysics

A novel PEX14/PEX5 interface links peroxisomal protein import and receptor recycling

L. Emmanouilidies, J. Sehr, K. Reglinski, S. Gaussmann, D. Goricanec, J. Kordon, F. Menezes, D. Waithe, P. Hublitz, V. Bader, K. F. Winklhofer, M. Jung, W. Schliebs, C. Eggeling, R. Erdmann, M. Sattler

This paper identifies a novel PEX14/PEX5 interface involved in peroxisomal protein import and receptor recycling through biochemical and structural analysis.

bioRxiv · Aug 8, 2023 · PreprintBiochemistry

SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells

L. P. Swift, B. C. Lagerholm, H. T. Baddock, L. R. Henderson, M. Ratnaweera, B. Sengerova, S. Y. Lee, A. Cruz-Migoni, D. Waithe, C. Renz, H. D. Ulrich, J. A. Newman, C. J. schofield, P. J. McHugh

This study shows that SNM1A is essential for repairing complex DNA breaks by removing chemically modified ends, enhancing radiation sensitivity in its absence.

bioRxiv · Jul 21, 2022 · PreprintBiochemistry

Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5

S. Galiani, K. Reglinski, P. Carravilla, A. Barbotin, I. Urbancic, J. Ott, J. Sehr, E. Sezgin, F. Schneider, D. Waithe, P. Hublitz, W. Schliebs, R. Erdmann, C. Eggeling

The paper characterizes the diffusion and interaction dynamics of PEX5 in the cytosol using advanced microscopy techniques, revealing a novel interaction partner.

bioRxiv · May 25, 2021Biophysics

Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

E. Arnaiz, A. Miar, A. G. Dias, N. Prasad, U. Schulze, D. Waithe, J. Rehwinkel, A. L. Harris

The paper shows hypoxia reduces mitochondrial double-stranded RNA production in breast cancer cells, leading to decreased type I IFN signaling and immunosuppression.

bioRxiv · Jul 31, 2020Cancer Biology

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

G. Juban, N. Sakakini, H. Chagraoui, Q. Cheng, K. Soady, B. Stoilova, C. Garnett, D. Waithe, J. Doondeea, B. Usukhbayar, E. Karkoulia, M. Alexiou, J. Strouboulis, E. Morrissey, I. Roberts, , P. Vyas

This study identifies stage-specific differentiation delays caused by GATA1s in megakaryocytes, leading to increased immature cells and altered gene expression.

bioRxiv · Oct 3, 2019Cell Biology

Lipid composition but not curvature is a determinant of a low molecular mobility within HIV-1 lipid envelope

I. Urbancic, J. Brun, D. Shrestha, D. Waithe, C. Eggeling, J. Chojnacki

The paper investigates the factors affecting molecular mobility on HIV-1 lipid envelopes using STED-FCS, finding that lipid composition and rigidity, not curvature, determine low mobility.

bioRxiv · May 4, 2018Biophysics

Nanoscale spatio-temporal diffusion modes measured by simultaneous confocal and STED imaging

F. Schneider, D. Waithe, S. Galiani, J. Bernardino de la Serna, E. Sezgin, C. Eggeling

This study introduces LIESS-FCS, a method that simultaneously measures diffusion in confocal and STED modes to reveal nanoscale diffusion characteristics in live cell membranes.

bioRxiv · Mar 23, 2018Biophysics

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

J. M. Brown, N. A. Roberts, B. Graham, D. Waithe, C. Lagerholm, J. M. Telenius, S. De Ornellas, M. Oudelaar, I. Szczerbal, C. Babbs, M. T. Kassouf, J. R. Hughes, D. R. Higgs, V. J. Buckle

The paper shows that an erythroid-specific self-interacting chromatin domain forms before gene activation and does not depend on enhancer-promoter interactions.

bioRxiv · Dec 15, 2017Cell Biology

Polarity sensitive probes for super resolution STED microscopy

E. Sezgin, F. Schneider, V. Zilles, E. Garcia, D. Waithe, A. S. Klymchenko, C. Eggeling

This study evaluates polarity-sensitive dyes in super resolution STED microscopy to probe nanoscale membrane heterogeneity in cell-derived vesicles, live cells, and virus particles.

bioRxiv · Feb 9, 2017Biophysics