Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS
T. Warrier, B. E. Poulsen, S. Barkho, J. Bagnall, K. P. Romano, T. White, X. Yu, T. Kawate, P. H. Nguyen, K. Raines, K. Ferrara, A. Golas, M. Fitzgerald, A. Boeszoermenyi, V. Kaushik, , D. T. Hung
The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.
bioRxiv · Mar 16, 2024 · PreprintMicrobiology