Author

T. Warrier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

D. T. Hung· 4 shared B. E. Poulsen· 2 shared K. P. Romano· 2 shared P. H. Nguyen· 2 shared T. Kawate· 2 shared A. Boeszoermenyi· 1 shared A. Golas· 1 shared A. Krishnakumar· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

D. T. Hung

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Essential and virulence-related protein interactions of pathogens revealed through deep learning

I. R. Humphreys, J. Zhang, M. Baek, Y. Wang, A. Krishnakumar, J. Pei, I. Anishchenko, C. A. Tower, B. A. Jackson, T. Warrier, D. T. Hung, S. B. Peterson, J. D. Mougous, Q. Cong, D. Baker

This study uses deep learning to predict protein-protein interactions in bacterial pathogens, identifying new complexes involving essential genes and virulence factors, with half of tested predictions validated.

bioRxiv · Apr 12, 2024 · PreprintBiochemistry

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens

M. W. Tse, M. Zhu, B. Peters, E. Hamami, J. Chen, K. P. Davis, S. Nitz, J. Weller, T. Warrier, D. K. Hunt, Y. Morales, T. Kawate, J. L. Gaulin, J. H. Come, J. Hernandez-Bird, , P. C. Blainey

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

bioRxiv · Mar 26, 2024 · PreprintMicrobiology

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

T. Warrier, B. E. Poulsen, S. Barkho, J. Bagnall, K. P. Romano, T. White, X. Yu, T. Kawate, P. H. Nguyen, K. Raines, K. Ferrara, A. Golas, M. Fitzgerald, A. Boeszoermenyi, V. Kaushik, , D. T. Hung

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

bioRxiv · Mar 16, 2024 · PreprintMicrobiology

Mutations in pmrB confer cross-resistance to the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa

K. P. Romano, T. Warrier, B. E. Poulsen, P. H. Nguyen, A. R. Loftis, A. Saebi, B. L. Pentelute, D. T. Hung

The paper identifies mutations in pmrB conferring cross-resistance to POL7080 and colistin in Pseudomonas aeruginosa by linking resistance mechanisms to lipid A modifications.

bioRxiv · Mar 8, 2019Microbiology