Author

A. Gruss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

K. Gloux· 5 shared D. Halpern· 4 shared A. FOUET· 3 shared A. Pathania· 3 shared A. Solgadi· 3 shared J. Anba-Mondoloni· 3 shared C. Henry· 2 shared C. Lambert· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersMicrobiology

K. Gloux

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection

C. Lambert, M. Gaillard, P. Wongdontree, C. Bachmann, A. Hautcoeur, K. Gloux, T. Guilbert, C. Mechats, B. Prost, A. Solgadi, S. Abreu, M. Andrieu, C. Poyart, A. Gruss, A. FOUET

This study investigates the dual role of FabT in Streptococcus pyogenes, showing it is essential for infection but allows growth advantage in lipid-rich environments.

bioRxiv · Jun 7, 2023Microbiology

Oxidative Stress is Intrinsic to Staphylococcal Adaptation to Fatty Acid Synthesis Antibiotics

P. Wongdontree, A. Millan-Oropeza, J. Upfold, J.-P. Lavergne, D. Halpern, C. Lambert, A. Page, G. Kenanian, C. Grangeasse, C. Henry, A. Fouet, K. Gloux, J. Anba-Mondoloni, A. Gruss

This study shows that anti-FASII antibiotics induce oxidative stress in S. aureus, which enhances adaptation by improving eFA incorporation and survival.

bioRxiv · Sep 9, 2022Microbiology

Prophages divert Staphylococcus aureus defenses against host lipids

B. Zhou, A. Pathania, D. Pant, D. Halpern, P. Gaudu, P. Trieu-Cuot, A. Dias-Leao, C. Pagot, A. Solgadi, A. Gruss, K. Gloux

This study shows that prophages in Staphylococcus aureus modulate lipid incorporation into bacterial membranes, affecting antibiotic resistance and infection dynamics.

bioRxiv · Jan 27, 2022 · PreprintMicrobiology

(p)ppGpp/GTP and malonyl-CoA modulate Staphylococcus aureus adaptation to FASII antibiotics and provide a basis for synergistic bi-therapy

A. Pathania, J. Anba-Mondoloni, M. Gominet, D. Halpern, J. Dairou, L. Dupont, G. Lamberet, P. Trieu-Cuot, K. Gloux, A. Gruss

This paper shows that (p)ppGpp and malonyl-CoA modulate S. aureus adaptation to FASII antibiotics, and that combining a (p)ppGpp inducer with an anti-FASII drug blocks bacterial outgrowth.

mBio · Feb 23, 2021Peer-reviewedMicrobiology

Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics

G. Kenanian, C. Morvan, A. Weckel, A. Pathania, J. Anba-Mondoloni, D. Halpern, A. Solgadi, L. Dupont, C. Henry, C. Poyart, A. Fouet, G. Lamberet, K. Gloux, A. Gruss

This study shows that Staphylococcus aureus can adapt to FASII antibiotics by incorporating environmental fatty acids in host conditions, challenging the assumption of fatty acid stringency.

bioRxiv · Jun 17, 2019Microbiology