MicrobiologymBioPeer-reviewed
(p)ppGpp/GTP and malonyl-CoA modulate Staphylococcus aureus adaptation to FASII antibiotics and provide a basis for synergistic bi-therapy
A. Pathania, J. Anba-Mondoloni, M. Gominet…·A. Gruss
This paper shows that (p)ppGpp and malonyl-CoA modulate S. aureus adaptation to FASII antibiotics, and that combining a (p)ppGpp inducer with an anti-FASII drug blocks bacterial outgrowth.
DOI 10.1128/mbio.03193-20