Author

D. Halpern

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Gruss· 4 shared K. Gloux· 4 shared A. Pathania· 3 shared J. Anba-Mondoloni· 3 shared A. Fouet· 2 shared A. Solgadi· 2 shared C. Henry· 2 shared G. Kenanian· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

A. Gruss

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Oxidative Stress is Intrinsic to Staphylococcal Adaptation to Fatty Acid Synthesis Antibiotics

P. Wongdontree, A. Millan-Oropeza, J. Upfold, J.-P. Lavergne, D. Halpern, C. Lambert, A. Page, G. Kenanian, C. Grangeasse, C. Henry, A. Fouet, K. Gloux, J. Anba-Mondoloni, A. Gruss

This study shows that anti-FASII antibiotics induce oxidative stress in S. aureus, which enhances adaptation by improving eFA incorporation and survival.

bioRxiv · Sep 9, 2022Microbiology

Prophages divert Staphylococcus aureus defenses against host lipids

B. Zhou, A. Pathania, D. Pant, D. Halpern, P. Gaudu, P. Trieu-Cuot, A. Dias-Leao, C. Pagot, A. Solgadi, A. Gruss, K. Gloux

This study shows that prophages in Staphylococcus aureus modulate lipid incorporation into bacterial membranes, affecting antibiotic resistance and infection dynamics.

bioRxiv · Jan 27, 2022 · PreprintMicrobiology

(p)ppGpp/GTP and malonyl-CoA modulate Staphylococcus aureus adaptation to FASII antibiotics and provide a basis for synergistic bi-therapy

A. Pathania, J. Anba-Mondoloni, M. Gominet, D. Halpern, J. Dairou, L. Dupont, G. Lamberet, P. Trieu-Cuot, K. Gloux, A. Gruss

This paper shows that (p)ppGpp and malonyl-CoA modulate S. aureus adaptation to FASII antibiotics, and that combining a (p)ppGpp inducer with an anti-FASII drug blocks bacterial outgrowth.

mBio · Feb 23, 2021Peer-reviewedMicrobiology

Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics

G. Kenanian, C. Morvan, A. Weckel, A. Pathania, J. Anba-Mondoloni, D. Halpern, A. Solgadi, L. Dupont, C. Henry, C. Poyart, A. Fouet, G. Lamberet, K. Gloux, A. Gruss

This study shows that Staphylococcus aureus can adapt to FASII antibiotics by incorporating environmental fatty acids in host conditions, challenging the assumption of fatty acid stringency.

bioRxiv · Jun 17, 2019Microbiology