Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcripts
A. A. Smargon, D. Pant, S. Glynne, T. A. Gomberg, E. W. Yeo
This study shows that guided A>I snRNAs improve RNA base conversion efficiency and reduce off-target effects compared to ADAR-recruiting circular RNAs in human cells.
bioRxiv · Jun 12, 2024 · PreprintBiochemistry