ImmunologybioRxivPreprint
CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent
I. Popescu, M. E. Snyder, C. J. Iasella…·J. F. McDyer
The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.
DOI 10.1101/2021.06.02.446831