Author

B. B. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Chene· 1 shared A. Das· 1 shared A. F. Sander· 1 shared A. H. Wells· 1 shared A. J. Spiegel· 1 shared A. Morris· 1 shared A. Salanti· 1 shared A. Sharma· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Chene

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA

J. Y. A. Doritchamou, M. A. Nielsen, A. Chene, N. K. VIebig, L. E. Lambert, A. F. Sander, J.-P. Semblat, S. Hundt, S. Orr-Gonzalez, C. M. Janitzek, A. J. Spiegel, S. B. Clemmensen, M. L. Thomas, M. C. Nason, M. Snow-Smith, , P. E. Duffy

This study evaluates VAR2CSA-based placental malaria vaccines in Aotus monkeys, finding limited cross-reactivity and functional activity similar to human trials.

bioRxiv · Jun 24, 2022Immunology

CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

I. Popescu, M. E. Snyder, C. J. Iasella, S. J. Hannan, R. Koshy, R. Burke, A. Das, M. J. Brown, E. J. Lyons, S. C. Lieber, X. Chen, J. C. Sembrat, X. An, K. Linstrum, G. Kitsios, , J. F. McDyer

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

bioRxiv · Jun 2, 2021 · PreprintImmunology

Discovery of bactericides as an acute mitochondrial membrane damage inducer

R. Houston, Y. Sekine, M. B. Larsen, K. Murakami, D. P. Narendra, B. B. Chen, S. Sekine

The paper identifies Chlorhexidine and Alexidine as bactericides that induce acute mitochondrial membrane damage by altering inner mitochondrial membrane integrity and evoking a unique stress response.

bioRxiv · Apr 9, 2021Cell Biology