F. Syed

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk

The paper identifies miRNAs in human islets and EVs that change under inflammatory conditions and can serve as biomarkers for type 1 diabetes risk.

A discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo

This study shows that targeting the Ppp1r15a upstream open reading frame rescues translation and improves kidney function in sepsis by overcoming uORF-mediated repression.

Testosterone promotes intestinal replication and dissemination of Coxsackievirus B3 in an oral inoculation mouse model

This study shows testosterone increases intestinal replication and dissemination of Coxsackievirus B3 in mice and alters the immune response to the virus.

ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

Abnormalities in Proinsulin Processing in Islets from Individuals with Longstanding T1D

The paper investigates proinsulin processing abnormalities in T1D islets, finding reduced processing enzymes and cytokine-induced expression changes.