Author

A. Hefner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

B. Beadle· 2 shared C. R. Pickering· 2 shared D. Molkentine· 2 shared H. D. Skinner· 2 shared J. Molkentine· 2 shared J. N. Myers· 2 shared L. Yang· 2 shared M. Abdelhakiem· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

B. Beadle

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3 papers

Recent·Most cited

Topographically driven microclimatic gradients shape patterns of forest structure, diversity, and composition at a forest-grassland transition zone

B. H. McNichol, R. Wang, A. Hefner, C. Helzer, S. M. McMahon, S. E. Russo

The paper quantifies how topographic and microclimatic gradients influence forest structure, diversity, and composition at a semi-arid forest-grassland transition zone.

bioRxiv · Sep 15, 2022 · PreprintEcology

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.

P. M. Pifer, L. Yang, M. Kumar, T. Xie, M. Frederick, A. Hefner, B. Beadle, D. Molkentine, J. Molkentine, A. Dhawan, M. Abdelhakiem, A. A. Osman, J. N. Myers, C. R. Pickering, V. C. Sandulache, , H. D. Skinner

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

bioRxiv · Jun 3, 2022Cancer Biology

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function.

M. Kumar, D. Molkentine, J. Molkentine, K. Bridges, T. Xie, L. Yang, A. Hefner, M. Gao, M. J. Frederick, S. Seth, M. Abdelhakiem, B. Beadle, F. M. Johnson, J. Wang, L. Shen, , H. D. Skinner

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

bioRxiv · Apr 10, 2020 · PreprintCancer Biology