N. Chomont

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4+ T-Cells by Decreasing Viral Release

This study shows metformin reduces HIV-1 virion release and increases antibody recognition of infected CD4+ T-cells by modulating BST2 and Bcl-2 expression in HIV-positive individuals on ART.

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

The paper identifies an X4-tropic HIV-1 transmitted/founder virus in a person with wild-type CCR5, showing faster CD4 depletion and resistance to certain bNAbs.

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

Detecting sources of immune activation and viral rebound in HIV infection

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections

This study identifies that HIV initially infects diverse CD4+ T cells in blood and lymph nodes, establishing both productive infections and latent reservoirs simultaneously.

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control

This study shows that infusing CCR5 gene-edited T cells improves immune function, reduces HIV reservoirs, and enables long-term viral control without ART.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

This study uses STIP-Seq to analyze HIV-1 reservoirs and identifies proviral features and cellular sources contributing to plasma viremia in ART-suppressed individuals.

Potential for virus endogenization in humans through testicular germ cell infection: the case of HIV

This study investigates whether HIV can integrate into human testicular germ cells, suggesting potential for endogenization.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.