A. Townsend

Urban soil microbiomes exhibit taxonomic and functional potential for enhanced contaminant cycling

The paper analyzes urban soil microbiomes to identify taxonomic and functional patterns linked to urbanization, revealing core microbial taxa and metabolic processes associated with urban environments.

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virus

This study characterizes human monoclonal antibodies against H7N9 avian influenza virus, identifies key epitopes, and evaluates escape mutants' impact on viral fitness and immune evasion.

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.

The paper identifies and characterizes influenza NP-specific CD8 T cells in porcine tissues, showing their persistence and gene expression changes in the lung.

Simultaneous aerosol and intra-muscular immunization with influenza vaccine induces powerful protective local T cell and systemic Ab immune responses in pigs

This study evaluates simultaneous aerosol and intramuscular influenza vaccination in pigs, finding that combined immunization induces both strong antibody and local T cell responses, leading to better virus control.

Neutralization of SARS-CoV-2 by destruction of the prefusion Spike

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

Distribution of droplets and immune responses after aerosol and intra-nasal delivery of influenza virus to the respiratory tract of pigs

This study compares droplet distribution and immune responses from different delivery methods of influenza virus in pigs, finding MAD delivers high lung dose with systemic immune activation.

Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

This study establishes a pig influenza model to evaluate monoclonal antibody efficacy against H1N1, showing dose-dependent reduction in viral load and lung pathology.

cGAMP loading enhances the immunogenicity of VLP vaccines

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

Broadly inhibiting anti-neuraminidase monoclonal antibodies induced by trivalent influenza vaccine and H7N9 infection in humans

This study identifies broadly reactive human monoclonal antibodies against N1 neuraminidase from vaccination and H7N9 infection, showing cross-inhibition of diverse N1 NAs and protective efficacy in mice.