Author

C. Deane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:proteomics· 4 Approach:deep learning· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

M. I. J. Raybould· 3 shared A. P. Lewis· 2 shared C. Marks· 2 shared C.-w. Chung· 2 shared J. R. Loeffler· 2 shared J. Shi· 2 shared M. L. Fernandez-Quintero· 2 shared O. Crook· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

M. I. J. Raybould

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Author profile →

8 papers

Recent·Most cited

Assessing AF2's ability to predict structural ensembles of proteins

J. R. Riccabona, F. C. Spoendlin, A.-L. M. Fischer, J. R. Loeffler, P. K. Quoika, T. P. Jenkins, J. A. Ferguson, E. Smorodina, A. H. Laustsen, V. Greiff, S. Forli, A. Ward, C. Deane, M. L. Fernandez-Quintero

This study evaluates AF2's ability to predict protein structural ensembles by comparing its results with MD simulations and NMR data for four test proteins.

bioRxiv · Apr 16, 2024Biophysics

Inferring residue level hydrogen deuterium exchange with ReX

O. Crook, N. Gittens, C.-w. Chung, C. Deane

ReX infers residue-level hydrogen deuterium exchange from HDX-MS data, showing improved performance in predicting unseen data and quantifying conformational changes in proteins.

bioRxiv · Apr 12, 2024 · PreprintBiochemistry

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

A. Huhn, D. A. Nissley, D. B. Wilson, M. A. Kutuzov, R. Donat, T. K. Tan, Y. Zhang, M. I. Barton, C. Liu, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, A. Townsend, W. S. James, G. Screaton, , O. Dushek

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

bioRxiv · Sep 6, 2023 · PreprintImmunology

PEP-Patch: Electrostatics in Protein-Protein Recognition, Specificity and Antibody Developability

F. Waibl, N. D. Pomarici, V. J. Hoerschinger, J. R. Loeffler, C. Deane, G. Georges, H. Kettenberger, M. L. Fernandez-Quintero, K. R. Liedl

PEP-Patch quantifies and visualizes protein electrostatic potential to analyze protease specificity, antibody-antigen recognition, and predict antibody pharmacokinetics.

bioRxiv · Jul 14, 2023 · PreprintBiophysics

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

K. Fischer, A. Lulla, T. So, P. Pereyra-Gerber, M. I. J. Raybould, T. N. Kohler, T. S. Kaminski, J. C. Yam-Puc, R. Hughes, F. Leiss-Maier, P. Brear, N. J. Matheson, C. Deane, M. Hyvonen, J. Thaventhiran, F. Hollfelder

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

bioRxiv · Jan 10, 2023Immunology

A functional Bayesian model for hydrogen-deuterium exchange mass-spectrometry

O. Crook, C.-w. Chung, C. Deane

The paper introduces a Bayesian framework for analyzing HDX-MS data to improve uncertainty quantification and model selection in protein conformational studies.

bioRxiv · Jul 18, 2022Biophysics

Evidence of Antibody Repertoire Functional Convergence through Public Baseline and Shared Response Structures

M. I. J. Raybould, C. Marks, A. Kovaltsuk, A. P. Lewis, J. Shi, C. Deane

The paper investigates functional convergence in human antibody repertoires by analyzing structural commonality in baseline and response antibodies, finding high structural similarity across individuals.

bioRxiv · Mar 17, 2020Immunology

Thera-SAbDab: the Therapeutic Structural Antibody Database

M. I. J. Raybould, C. Marks, A. P. Lewis, J. Shi, A. Bujotzek, B. Taddese, C. Deane

Thera-SAbDab tracks therapeutic antibodies and nanobodies, linking them to structural data and metadata for sequence and target analysis.

bioRxiv · Aug 12, 2019Immunology