A. I. Barakat

This paper develops a computational model to predict platelet plug formation under chemical and mechanical stimuli, showing the importance of shear gradients in thrombosis.

This study investigates contact guidance in single endothelial cells and monolayers, finding distinct mechanisms: single cells rely on protrusion persistence, while monolayers depend on basement membrane organization.

This study identifies PPP2R1A's role in migration persistence via the WAVE Shell Complex, showing its tumor suppressor function through actin regulation.

This study shows that unconfined endothelial cell monolayers on microgrooved substrates exhibit periodic anti-parallel collective migration, driven by physical constraints on cell orientation.

This paper introduces a microvessel-on-chip system that uses luminal flow actuation to generate physiologically relevant wall shear stress and circumferential strain.

This study shows that leukocytes become significantly stiffer and more viscous within seconds of contact with target cells, with mechanical properties evolving in parallel and maintaining a cell-type-specific ratio.