C. Leclech

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformations

This study uses microgroove substrates to show that adherent cells exhibit dynamic 3D nuclear deformations driven by adhesion, with implications for diagnosing nuclear mechanical disorders.

Distinct contact guidance mechanisms in single endothelial cells and in monolayers

This study investigates contact guidance in single endothelial cells and monolayers, finding distinct mechanisms: single cells rely on protrusion persistence, while monolayers depend on basement membrane organization.

Topography-induced large-scale anti-parallel collective migration in vascular endothelium

This study shows that unconfined endothelial cell monolayers on microgrooved substrates exhibit periodic anti-parallel collective migration, driven by physical constraints on cell orientation.

Topographical cues control the morphology and dynamics of migrating cortical interneurons

This study shows that micro-scale topography influences the morphology and migration of cortical interneurons in vitro, promoting distinct migratory states.