Cancer BiologybioRxivPreprint
Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production
E. N. Perrault, J. M. Shireman, E. S. Ali…·A. U. Ahmed
This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.