A. Basu

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

The paper uses proximity labeling to study the dynamic SQSTM1 protein network and shows that aggregated tau alters its interactions with stress-associated proteins.

Phase separated liquid vimentin droplets stabilize actin fibers through wetting

This study shows vimentin forms liquid droplets that stabilize actin fibers by wetting them, and this behavior is observed in both a mutant and wild-type vimentin.

Determinants of raffinose family oligosaccharide use in Bacteroides species

This study identifies mutations that enhance Bacteroides thetaiotaomicron's utilization of raffinose family oligosaccharides by increasing BT1871 expression and shows the role of PUL22 hydrolases and BT4338 in this process.

ERK5 Signaling is Required for Type III IFN-mediated Mucosal Antiviral Responses

The paper identifies ERK5 as a potentiator of STAT1 activation and ISG expression, enhancing type III IFN-mediated antiviral responses in epithelial cells.

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

Experimental evolution for improved post-infection survival selects for increased disease resistance in Drosophila melanogaster

This study shows that experimental evolution of Drosophila melanogaster under post-infection survival selection leads to increased disease resistance but not disease tolerance.

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.

Exploring the tumor micro-environment in ovarian cancer histotypes and tumor sites

This study uses single-cell RNA sequencing to analyze ovarian cancer histotypes and tumor sites, identifying cell compositions, marker genes, and ligand-receptor pairs in the tumor microenvironment.

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

This study identifies genes and pathways in B. fragilis that affect its fitness in bile acids, using a barcoded mutant library and transcriptomic analysis.

Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes

This study uses computational drug repositioning to identify agents that can sensitize drug-resistant breast tumors, finding fulvestrant effective across multiple treatment and receptor subtypes.

Dependence of Nucleosome Mechanical Stability on DNA Mismatches

This study investigates how DNA mismatches affect nucleosome mechanical stability and DNA exposure using single-molecule techniques, finding that C-C mismatches increase stability and reduce accessibility.

Integration of silicon chip microstructures for in-line microbial cell lysis in soft microfluidics

The paper develops a method to integrate silicon microstructures into soft microfluidic devices for in-line microbial cell lysis using piezoelectric actuation.

Selection for increased post-infection survival ameliorates mating induced immune suppression in Drosophila melanogaster females

This study shows that Drosophila melanogaster populations selected for increased post-infection survival show reduced mating-induced immune suppression compared to control populations.

Correlated responses to experimental evolution of increased post-infection survival in Drosophila melanogaster: Life-history trade-offs and reaction to novel stressors

This study shows that Drosophila melanogaster can rapidly evolve increased resistance to E. faecalis infection without life-history costs or abiotic stress resistance.

Pathogen dependence and inter-individual variability of post-infection reproductive fitness in Drosophila melanogaster

This study investigates how bacterial infections affect reproductive fitness in Drosophila melanogaster, finding that pathogen identity predicts population-level responses but not individual variability, and that infected females that survive show reproductive output similar to uninfected controls.

Discordant effects of resource limitation on host survival and systemic pathogen growth in Drosophila-bacteria infection models: resistance vs. tolerance

This study examines how resource limitation through starvation and sexual activity affects host survival and pathogen growth in Drosophila infected with bacterial pathogens, finding pathogen-specific outcomes.

Recurrent evolution of cross-resistance in response to selection for improved post-infection survival in Drosophila melanogaster

This study shows that selecting Drosophila melanogaster for resistance to one bacterial pathogen leads to generalized cross-resistance against other pathogens.

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.

Image quantification technique reveals novel lung cancer cytoskeletal phenotype with partial EMT signature

The paper identifies an intermediate EMT state with a specific cytoskeletal signature using image quantification tools and tracks EMT progression and drug responses.

Tracing the Indian Population Ancestry by cis-linked Mutations in HBB Gene

The paper identifies cis-linked mutations in the HBB gene among Indian thalassemia patients to trace the migratory route of the Ancestral North Indian population.

Lightweight Reinforcement Algorithms for autonomous, scalable intra-cortical Brain Machine Interfaces

This paper introduces Banditron, a lightweight RL algorithm for iBMIs, showing significant power savings and performance improvements over state-of-the-art methods.

Retinoic Acid Inducible Gene-I like Receptors Activate Snail and Slug to Limit RNA Viral Infections

The paper shows that RLRs activate Snail and Slug to limit RNA viral infections by regulating their transcription and enhancing the antiviral response.

Alternative MyD88 -Cyclin D1 signaling in breast cancer cells regulates TLR3 mediated cell proliferation

This study shows that TLR3 ligand promotes breast cancer cell proliferation via the MyD88-Cyclin D1 pathway, with MyD88 inhibition blocking this effect.

Inhibition of Streptococcus pneumoniae autolysins highlight distinct differences between chemical and genetic inactivation

The paper identifies a diamide inhibitor of Streptococcus pneumoniae growth and shows that genetic and chemical inactivation of autolysins yield different phenotypic outcomes.

Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

This study evaluates the safety and immunogenicity of a SARS-CoV-2 vaccine BBV152 in mice, rats, and rabbits, showing high antibody titers and Th1-biased responses with the TLR7/8 agonist adjuvant.

Deciphering the mechanical code of genome and epigenome

This study identifies a mechanical code linking DNA sequence to mechanical properties, showing how CpG methylation and sequence features influence DNA shape and gene regulation.

Measuring DNA mechanics on the genome scale

This paper develops loop-seq to measure DNA bendability genome-wide and finds sequence-encoded low bendability upstream of TSSs that influences nucleosome positioning and chromatin remodeling.

Performance of Abbott ID NOW COVID-19 rapid nucleic acid amplification test in nasopharyngeal swabs transported in viral media and dry nasal swabs, in a New York City academic institution

This study evaluates the Abbott ID NOW COVID-19 assay's performance compared to Cepheid Xpert Xpress SARS-CoV-2 using different sample types and transport methods.

Whole genomes reveal severe bottleneck among Asian hunter-gatherers following the invention of agriculture

The paper uses whole genome sequences to show that Asian hunter-gatherers experienced population declines after agriculture began, likely due to displacement, enslavement, and disease.

Expression of Toll like Receptor 4 in the ductal epithelial cells of the Breast tumor microenvironment is correlated with the invasiveness of the tumor

The paper investigates TLR4 expression in breast tumors and finds it correlates with invasiveness and lymph node involvement, with differential effects in TP53 wild-type and mutant cells.