O. W. Lee

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

This study identifies small molecule activators of human fumarate hydratase through quantitative high-throughput screening, revealing compounds that enhance FH activity without being substrates or redox agents.

The paper profiles cytotoxicity of over 100,000 compounds across normal and cancer cell lines to identify cytotoxic compounds and improve screening efficiency.

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.