ZEB2 transduces HIF1α dependent regulation of Transglutaminase 2 in glomerular podocytes
This study shows HIF1 stabilization increases ZEB2 and TRPC6, which enhance TG2 expression and activity, leading to glomerular injury.
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5 papers
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This study shows HIF1 stabilization increases ZEB2 and TRPC6, which enhance TG2 expression and activity, leading to glomerular injury.
R. NISHAD, D. Mukhi, A. K. Singh…·A. k. Pasupulati
This study shows that growth hormone induces TGF-β1 signaling and causes mitotic catastrophe in podocytes, leading to proteinuria in diabetic nephropathy.
S. N. Mulukala, V. Kambhampati, A. S. Qadri, A. k. Pasupulati
This study analyzes the evolutionary distribution and conservation of slit-diaphragm proteins across vertebrates and invertebrates, revealing conserved domains and the importance of intrinsically unstructured regions.
S. K. K. Mulukala Narasimha, S. S. Irukuvajjula, K. Kumar…·A. k. Pasupulati
This study investigates the oligomeric structure of a truncated podocin domain, showing it primarily forms a 16mer with significant secondary structure and moderate tertiary packing.
K. Nakuluri, R. Nishad, D. Mukhi…·A. K. Pasupulati
This study identifies the HIF1α/ZEB2 axis as a novel mechanism inducing TRPC6 and causing podocyte dysfunction and proteinuria during cerebral ischemia.