Author

A. Kaech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:development & morphogenesis· 3 Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Assay:imaging· 1

Frequent Co-Authors

A. Spang· 3 shared C. E. Cadena del Castillo· 2 shared A. Badugu· 1 shared B. Rathkolb· 1 shared C. Bürer· 1 shared D. Hoces· 1 shared D. P. Ott· 1 shared D. S. Froese· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

A. Spang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Coordination between ESCRT function and Rab conversion during endosome maturation

D. P. Ott, S. Desai, J. A. Solinger, A. Kaech, A. Spang

The paper shows that ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are coordinated, with ESCRTs and ubiquitinated cargo regulating Rab conversion timing.

bioRxiv · May 14, 2024Cell Biology

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

M. Lucienne, R. Gerlini, B. Rathkolb, J. Calzada-Wack, P. Forny, S. Wüest, A. Kaech, F. Traversi, M. Forny, C. Bürer, J. A. Aguilar-Pimentel, M. Irmler, J. Beckers, S. Sauer, S. Kölker, , M. Hrabe de Angelis

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

bioRxiv · Nov 30, 2021Physiology

The C. elegans PTCHD homolog PTR-4 is required for proper organization of the pre-cuticular apical extracellular matrix

J. D. Cohen, C. E. Cadena del Castillo, A. Kaech, A. Spang, M. V. Sundaram

This study identifies PTR-4 as essential for organizing the pre-cuticular apical extracellular matrix in C. elegans, with defects in cuticle formation and function in its absence.

bioRxiv · Mar 30, 2021 · PreprintCell Biology

Cytoplasmic flows caused by actomyosin contraction drive interkinetic nuclear migration

A. Badugu, A. Kaech

The paper shows that cytoplasmic flows, driven by actomyosin contraction, cause interkinetic nuclear migration in Drosophila wing discs.

bioRxiv · Apr 9, 2020 · PreprintBiophysics

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

C. E. Cadena Del Castillo, J. T. Hannich, A. Kaech, H. Chiyoda, M. Fukuyama, N. J. Færgeman, H. Riezman, A. Spang

This study identifies PTC-3 as a cholesterol transporter in C. elegans, showing that its loss causes cholesterol accumulation, ER defects, and lipid metabolism issues, which are rescued by reducing dietary cholesterol.

bioRxiv · Oct 23, 2019Cell Biology