S. Sauer

Oncogene inactivation-induced senescence facilitates tumor relapse

This study shows that oncogene inactivation-induced senescence both limits tumor growth and promotes relapse by creating a pro-recurrence microenvironment.

From in vitro to in silico: a pipeline for generating virtual tissue simulations from real image data

The paper develops an accessible pipeline for generating virtual tissue simulations from real 3D image data using open-source software and the Cellular Potts Model.

A Multiparametric Analysis Reveals Differential Behavior of Spheroid Cultures on Distinct Ultra-Low Attachment Plates Types

This study compares spheroid formation and behavior across six ultra-low attachment plate types using four human cell lines, finding size and eccentricity differences that suggest plate type impacts experimental outcomes.

Cell Atlas at Single-Nuclei Resolution of the Adult Human Adrenal Gland and Adrenocortical Adenomas

This study creates a single-nuclei cell atlas of the adult human adrenal gland and adrenocortical adenomas, revealing progenitor cell populations and tumor heterogeneity.

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

The paper shows that non-productive exposure of PBMCs to SARS-CoV-2 triggers JAK/STAT-dependent innate immune responses in monocytes, similar to those seen in mild COVID-19.

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens

The paper identifies urban-specific bacteria in freshwater ecosystems, including potential pathogens, showing urbanization alters microbial communities and creates health risks.

Dissecting HSV-1-induced host shut-off at RNA level

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

Resolving fate and transcriptome of hematopoietic stem cell clones

The paper develops a method to study hematopoietic stem cell clones and finds they have distinct transcriptional profiles and fate outcomes.