M. Keller

A plant-specific clade of serine/arginine-rich proteins regulates RNA splicing homeostasis and thermotolerance in tomato

This study identifies RS2Z35 and RS2Z36 as plant-specific splicing factors that regulate HSFA2 intron splicing and thermotolerance in tomato under heat stress.

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

NYUS.2: an Automated Machine Learning Prediction Model for the Large-scale Real-time Simulation of Grapevine Freezing Tolerance in North America

The paper develops NYUS.2, an automated machine learning model for real-time simulation of grapevine freezing tolerance in North America, outperforming previous models with lower error.

hGRAD - a versatile 'one-fits-all' system for the acute depletion of RNA binding proteins in nuclear condensates

hGRAD rapidly depletes nuclear RNA binding proteins, enabling study of their roles in RNA processing and dynamics.

Tracking canopy gap dynamics across four sites in the Brazilian Amazon

The paper uses remote sensing to analyze canopy gap dynamics across four Amazon regions, finding that gap recovery rates vary with environmental factors.

Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic

This study determines the minimum infective dose of SARS-CoV-2 for Golden Syrian hamsters and highlights their high susceptibility, suggesting a potential zoonotic risk.

Live-cell microscopy or fluorescence anisotropy with budded baculoviruses - which way to go with measuring ligand binding to M4 muscarinic receptors?

The paper compares fluorescence anisotropy and live-cell microscopy for measuring ligand binding kinetics to M4 muscarinic receptors, finding both methods suitable for affinity and kinetics analysis.

Tracking the rates and mechanisms of canopy damage and recovery following Hurricane Maria using multitemporal lidar data

This study quantifies forest damage and recovery after Hurricane Maria using lidar data, finding widespread canopy loss and heterogeneous regrowth patterns.

European agroforestry is no universal remedy for biodiversity: a time-cumulative meta-analysis

This study finds agroforestry does not universally boost biodiversity, with benefits only in silvoarable systems over conventional agriculture, but results are inconsistent and influenced by unmeasured factors.

Pitfalls in SARS-CoV-2 PCR diagnostics

This study identifies contamination of commercial PCR reagents as a source of false positives in SARS-CoV-2 testing, emphasizing the need for rigorous validation of reagents before use.

Physical constrains and functional plasticity of cellulases: Linear scaling relationships for a heterogeneous enzyme reaction

The paper characterizes 83 cellulases, revealing a linear free energy relationship between substrate binding strength and activation barrier, suggesting physical constraints and evolutionary optimization in interfacial enzyme catalysis.

Resource availability and disturbance shape maximum tree height across the Amazon

This study identifies environmental factors influencing the distribution of extremely tall trees in the Amazon using LiDAR data, finding wind speed as the strongest predictor.

Ancient Yersinia pestis genomes provide no evidence for the origins or spread of the Justinianic Plague

The paper reanalyzes ancient Yersinia pestis genomes to challenge the link between the Justinianic Plague and the identified genomes, suggesting the lower coverage genome may instead relate to the Black Death.

The first functional characterization of ancient interleukin-15-like (IL-15L) reveals shared and distinct functions of the IL-2, -15 and -15L family cytokines

This study characterizes the functional roles of IL-15L in rainbow trout, revealing shared and distinct functions compared to IL-2 and IL-15, and provides insights into cytokine family evolution.

Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541-750)

This study reconstructs six new Yersinia pestis genomes from the First Pandemic (541-750) and identifies genetic diversity and potential convergent evolution with later pandemics.

A phylogeography of the second plague pandemic revealed through the analysis of historical Y. pestis genomes

This study analyzes historical Y. pestis genomes to trace the phylogeography of the second plague pandemic, revealing patterns of genetic diversity and virulence gene loss.