A. Agrawal

Intra-Lymph Node Crosslinking of Antigen-Bearing Polymers Enhances Humoral Immunity and Dendritic Cell Activation

This paper describes a novel vaccination platform using crosslinking polymers to enhance humoral immunity and dendritic cell activation in lymph nodes without adjuvants.

A TLR7 Agonist Conjugated to a Nanofibrous Peptide Hydrogel as a Potent Vaccine Adjuvant

This paper conjugates a TLR7 agonist to a peptide hydrogel to create a vaccine adjuvant that produces antibody titers similar to alum and a more balanced Th1/Th2 immune response.

The Molecular Picture of the Local Environment in a Stable Model Coacervate

This paper uses molecular dynamics simulations to study ion dynamics in PDDA-ATP coacervates, showing that transferring to DI water causes ion ejection and structural changes that stabilize the coacervates.

Universal Cell Embeddings: A Foundation Model for Cell Biology

The paper introduces UCE, a foundation model that creates a universal cell embedding space from single-cell data across species, enabling new insights into cell organization and function.

Cardiac glycosides protect wormseed wallflower (Erysimum cheiranthoides) against some, but not all, glucosinolate-adapted herbivores

The paper investigates how cardiac glycosides in Erysimum cheiranthoides affect herbivore interactions, finding they protect against some but not all glucosinolate-tolerant herbivores.

Engineering Y. lipolytica for the biosynthesis of geraniol

This paper engineers Yarrowia lipolytica to produce geraniol, achieving a high titer of 1 g/L through metabolic pathway optimization and gene overexpression.

Urbanization and a green corridor do not impact genetic divergence in common milkweed (Asclepias syriaca)

The study tests if urbanization and green corridors affect genetic divergence in common milkweed, finding no impact on trait genetics despite phenotypic variation.

3D Confinement-enabled Priming of Synaptic Activation Promotes Primary T Cell Expansion

This paper introduces a 3D confinement method to prime T cell-MHC immune synapses, achieving faster T cell expansion compared to conventional methods.

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

Cell-Sized Lipid Vesicles as Artificial Antigen-Presenting Cells for Antigen-Specific T Cell Activation

This study demonstrates artificial antigen-presenting cells (aAPCs) that activate T cells efficiently, showing significant increases in IFN-gamma secretion and T cell expansion without additional stimulants.

Profiling Dynamic Patterns of Single-cell Motility

This study introduces CaMI, a framework to classify single-cell motility patterns, revealing heterogeneity and dynamics not captured by traditional ensemble methods.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

Dendrite architecture determines mitochondrial distribution patterns in vivo

The paper shows that mitochondrial distribution in Drosophila dendrites follows scaling rules based on dendrite morphology, independent of neuronal activity.

Cell walls are dynamically O-acetylated in the green seaweed, Ulva compressa

The paper identifies O-acetylation in Ulva compressa cell wall polymers, showing dynamic changes under stress and potential gene involvement.

Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome-lysosome fusion in dystrophin-deficient mdx mice

This study shows that inhibiting HDAC6 increases tubulin acetylation and autophagosome-lysosome fusion in dystrophin-deficient mdx mice, improving muscle function and reducing damage.

Temporal matches and mismatches between monarch butterfly and milkweed population changes over the past 12,000 years

The paper analyzes the demographic history of monarch butterflies and milkweed over 12,000 years, finding concurrent range expansions but no recent population contractions in either species.

Age-Related Impairment of Innate and Adaptive Immune Responses Following Intranasal Herpes Simplex Infection

This study investigates age-related immune impairments in mice following HSV-1 infection, finding reduced type-I interferon production and impaired CD8+ T cell function in aged mice.

Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of airway allergic inflammation

This study shows that obesity impairs MSCs' ability to perform mitophagy and intercellular mitochondrial transfer, and that PQQ can restore these functions in obese-derived MSCs.

Models of the cardiac L-type calcium current: a quantitative review

This paper reviews 73 mammalian models of the cardiac L-type calcium current, finds large variability in their predictions, and provides model code and data sources.

Plant defense synergies and antagonisms affect performance of specialist herbivores of common milkweed

The paper tests defense synergies in common milkweed by analyzing herbivore performance and identifies synergistic and antagonistic interactions between defense traits.

Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by slowing luminal transport

The paper shows RTN4/NOGO regulates ER morphology, which modulates luminal transport and Ca2+ delivery, affecting axonogenesis in neurons.

Phospholipids stabilize binding of pituitary adenylate cyclase-activating peptide to vasoactive intestinal polypeptide receptor

The paper shows phospholipids stabilize PACAP27 binding to VIP1R by lowering binding free energy through specific lipid interactions.

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

Lateral electric field inhibits gel-to-fluid transition in lipid bilayers

The paper shows lateral electric fields increase the melting temperature of lipid bilayers in simulations, suggesting new insights into lipid interactions under electric fields.

Quantification of in-plane flexoelectricity in lipid bilayers

The paper quantifies in-plane flexoelectricity in lipid bilayers using molecular dynamics simulations and computes an effective in-plane flexoelectric coefficient for four lipid types.

Optimizing Mitochondrial Maintenance in Extended Neuronal Projections

This study develops mathematical models to analyze mitochondrial maintenance strategies in neurons, finding that infrequent exchange and selective recycling optimize mitochondrial health.

Docosahexaenoic acid (DHA), a nutritional supplement, modulates steroid insensitivity in asthma

This study shows DHA improves steroid sensitivity in asthma models and is lower in steroid-insensitive asthmatics.

Electromechanics of lipid-modulated gating of Kv channels

The paper investigates how anionic lipids and cholesterol modulate Kv channel gating through electrostatic and mechanical interactions, showing lipid-specific effects on channel activity.

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

Less Is More: A Mutation in the Chemical Defense Pathway of Erysimum cheiranthoides (Brassicaceae) Reduces Total Cardenolide Abundance but Increases Resistance to Insect Herbivores

This study shows a mutation in Erysimum cheiranthoides reduces total cardenolide abundance but increases resistance to two herbivore species.