A. Gibson

Still Not Sterile: Chlorhexidine gluconate treatment does not completely reduce skin microbial bioburden and promotes pathogen overabundance in patients undergoing elective surgeries.

This study shows that chlorhexidine gluconate reduces viable skin microbial bioburden but does not achieve complete sterility, and temporarily increases pathogen abundance before microbiome recovery.

Pond Water Microbiome Taxa Profiles and Antibiotic Resistance Genes Associated with Acidity and Tannins

The paper analyzes microbial taxa and antibiotic resistance genes in four ponds, linking their prevalence to environmental factors like pH and tannins.

Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.

Integrative analysis of nanopore direct RNA sequencing data reveals a role of PUS7-dependent pseudouridylation in regulation of m6A and m5C modifications

The paper introduces NanoPsiPy, a pipeline for detecting pseudouridylation sites using nanopore sequencing, and shows PUS7-dependent pseudouridylation affects m6A and m5C levels.

Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis.

The paper uses multiomic single-cell sequencing to analyze SJS/TEN patients' skin and blister fluid, identifying tissue-specific immune responses and T-cell clonotypes involved in pathogenesis.

What is Slough?A pilot study to define the proteomic and microbial composition of wound slough and its implications for wound healing.

This study characterizes the proteomic and microbial composition of wound slough and integrates these with clinical data to predict wound healing outcomes.

Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

The paper shows that dissociation methods bias transcriptomes in sarcoma single-cell and single-nucleus RNA-seq, and demonstrates computational correction of these biases.

Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality

This study identifies a SNP in bovine TLR2 that contributes to breed-specific differences in innate immune response to mycobacterial antigens.

Crosstalk between enterocytes and innate lymphoid cells drives early IFN-g-mediated control of Cryptosporidium

This study shows enterocytes promote ILC production of IFN-gamma, which restricts Cryptosporidium growth by acting on enterocytes themselves.

Trade-offs between antiseptic cytotoxicity and efficacy in a human ex vivo wound contamination model

The paper evaluates the cytotoxicity and efficacy of five antiseptics in an ex vivo human wound model, finding chlorhexidine gluconate reduces microbial counts but harms tissue viability.

Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms

This study investigates how priority effects and competitive exclusion shape fungal-bacterial biofilm communities and influence virulence in chronic wounds.

Modelling early thermal injury using an ex vivo human skin model of contact burns

This study develops an ex vivo human skin model to simulate contact burns and assesses inter-individual variability in tissue injury and healing over time.