M. Shirouzu

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

This study identifies how p300/CBP reads and writes histone acetylation to propagate epigenetic marks and activate gene transcription.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

Structural basis for activation of DNMT1

This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.

Structural basis for the assembly and electron transport mechanisms of the dimeric photosynthetic RC-LH1 supercomplex

The paper reports cryo-EM structures of the dimeric RC-LH1 supercomplex from Rhodobacter sphaeroides, revealing the architecture, assembly mechanism, and electron transport pathways involving PufX and PufY.

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

GTP-dependent formation of straight oligomers leads to nucleation of microtubules

The paper shows that GTP-dependent formation of straight oligomers is essential for microtubule nucleation, with a mutation increasing straight oligomers and accelerating nucleation.

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.