A. Kimura

Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven intracellular transport along microtubules

This study shows that cytoplasmic actomyosin fluctuations enhance dynein-driven transport in C. elegans embryos by accelerating motor-cargo movement through asymmetric force responses.

Live-cell imaging under centrifugation characterized the cellular force for nuclear centration in the Caenorhabditis elegans embryo

The paper measures cellular forces for nuclear centration in C. elegans embryos using centrifugation and microscopy, finding forces increase linearly with distance and friction is reduced in microtubule mutants.

Enucleation of the C. elegans embryo revealed the mechanism of dynein-dependent spacing between microtubule asters

The paper uses enucleated C. elegans embryos to study dynein-dependent centrosome spacing mechanisms and identifies a dynein-independent movement in later cell cycles.

Sequential accumulation of dynein and its regulatory proteins at the spindle region in the Caenorhabditis elegans embryo

The paper investigates the sequential accumulation of dynein and its regulatory proteins at the spindle region in C. elegans embryos, revealing distinct spatiotemporal patterns and the role of NUD-2's C-terminal helix in pre-NEBD accumulation.

The extra-embryonic space is a geometric constraint regulating cell arrangement in nematodes

The paper shows that extra-embryonic space in nematodes influences cell arrangement by affecting geometric constraints in the 4-cell stage embryo.

Evaluation of microbial diversification mechanisms in legume-based mixed cropping systems with different legume species and types of fertilizer management

This study evaluates how different legume species and fertilizer types affect soil microbial diversity in mixed cropping systems using 16S rRNA analysis.

Multiplexed 129Xe HyperCEST MRI detection of genetically-reconstituted bacterial protein nanoparticles in human cancer cells.

The paper genetically reconstitutes bacterial protein nanoparticles in human cancer cells and demonstrates their use as contrast agents for HyperCEST MRI.

Elasticity and Topography-Controlled Collagen Hydrogels Mimicking Native Cellular Milieus

This study develops collagen hydrogels that mimic native ECM by combining elasticity, topography, and composition, showing topography overrides elasticity in controlling cell morphology.

Pivotal involvement of the CX3CL1-CX3CR1 axis for the recruitment of M2-TAMs in skin carcinogenesis

The paper investigates the role of the CX3CL1-CX3CR1 axis in skin carcinogenesis, finding that it promotes tumor-associated macrophage recruitment and function, contributing to cancer progression.

Cold Vacuum Extracts of Double Cherry Blossom (Gosen-Sakura) Leaves Show Antitumor Activity

This study extracts and tests compounds from Gosen-Sakura leaves, finding novel antitumor compounds that inhibit tumor cell proliferation.

Impaired chromosome segregation results in sperms with excess centrosomes in emb-27APC6 mutant C. elegans

This study shows that emb-27 mutants in C. elegans have excess centrosomes in sperms, leading to zygotes with excess centrosomes and reduced spermatid numbers.

Choice between 1- and 2-furrow cytokinesis in Caenorhabditis elegans embryos with tripolar spindles

The paper investigates how Caenorhabditis elegans embryos with tripolar spindles form 1 or 2 cytokinetic furrows, finding that cell shape, cortical forces, and centrosome size determine this outcome.

Microinjection into the Caenorhabditis elegans embryo using an uncoated glass needle enables cell lineage visualization and reveals cell-non-autonomous adhesion control

This study develops a microinjection method for C. elegans embryos using an uncoated glass needle, enabling lineage tracking and revealing cell-non-autonomous adhesion control.

The tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division

This study identifies APC as an attenuator of spindle-pulling forces during C. elegans asymmetric cell division, showing it stabilizes microtubule plus-ends and reduces catastrophe frequency.

An Anisotropic Attraction Model For The Diversity And Robustness Of Cell Arrangement In Nematodes

The paper shows that changing eggshell shape in C. elegans embryos can reproduce diverse cell arrangement patterns, and attraction forces from cell adhesion ensure robustness.