T. M. Watanabe

This paper develops a method to estimate crossbridge-state in cardiomyocytes using SHG polarization, showing its applicability in assessing myosin force generation and drug effects.

The paper tracks Nanog and Oct4 in mouse embryonic stem cells to study their roles in pluripotency, finding that Nanog interacts longer with targets during differentiation, suggesting a feedback mechanism.

This study shows VCP regulates FUS granule stability by consuming ATP inside the granules, acting as a timer to prevent persistent granules that lead to ALS pathology.

The paper introduces an imaging system to observe rare cellular activity in over one million cells and demonstrates its ability to detect rare events in biological systems.

The paper genetically reconstitutes bacterial protein nanoparticles in human cancer cells and demonstrates their use as contrast agents for HyperCEST MRI.

This paper introduces a new mathematical approach to qPCR data analysis that improves the precision of efficiency and gene expression ratio estimations compared to the classical calibration curve method.

This paper demonstrates the use of SHG polarization microscopy to detect protein conformational changes in macromolecular assemblies without labeling.