Author

A. L. Marcinkiewicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:proteomics· 3 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Y.-P. Lin· 6 shared A. P. Dupuis· 3 shared J. L. Stout· 3 shared T. A. Nowak· 3 shared A. D. Davis· 2 shared A. T. Ciota· 2 shared K. Strle· 2 shared M. A. Diuk-Wasser· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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6 shared papersMicrobiology

Y.-P. Lin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The structure of a hibernating ribosome in a Lyme disease pathogen

M. R. Sharma, S. R. Manjari, E. K. Agrawal, P. Keshavan, R. K. Koripella, S. Majumdar, A. L. Marcinkiewicz, Y.-P. Lin, R. K. Agrawal, N. K. Banavali

This study determines the structure of the hibernating ribosome in Borrelia burgdorferi using cryo-EM, revealing new structural features and insights into antibiotic binding.

bioRxiv · Apr 16, 2023Biochemistry

Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism

A. L. Marcinkiewicz, K. Brangulis, A. P. Dupuis, T. M. Hart, M. Zamba_Campero, T. A. Nowak, J. L. Stout, I. Akopjana, A. Kazaks, J. Bogans, A. T. Ciota, P. Kraiczy, S.-O. Kolokotronis, Y.-P. Lin

This paper identifies a minor sequence variation in the CspZ protein of Borrelia burgdorferi that influences host-specific complement evasion and infectivity through FH-binding interface differences.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

Co-infection of Ehrlichia with B. burgdorferi drives emergency myelopoiesis and promotes Lyme arthritis

J. L. Bonin, S. R. Torres, A. L. Marcinkiewicz, X. Yang, U. Pal, J. DiSpirito, T. Nowak, Y.-P. Lin, K. C. MacNamara

This study shows that co-infection with Ehrlichia and Borrelia burgdorferi in mice causes arthritis and emergency myelopoiesis, highlighting immune signals over pathogen burden in disease development.

bioRxiv · Aug 23, 2022 · PreprintImmunology

Phylogenomic diversity elucidates mechanistic insights into Lyme borreliae host association

M. A. Combs, A. L. Marcinkiewicz, A. P. Dupuis, A. D. Davis, P. Lederman, T. A. Nowak, J. L. Stout, K. Strle, V. Fingerle, G. Margos, A. T. Ciota, M. A. Diuk-Wasser, S.-O. Kolokotronis, Y.-P. Lin

This study investigates how genetic variation in Lyme disease-causing Borrelia burgdorferi strains relates to their ability to evade host complement immune responses, revealing host-specific complement-evasion phenotypes.

bioRxiv · May 25, 2022Microbiology

CspZ FH-binding sites as epitopes promote antibody-mediated Lyme borreliae clearance

Y.-L. Chen, A. L. Marcinkiewicz, T. A. Nowak, R. T. Kundu, Z. Liu, U. Strych, M.-E. Bottazzi, W.-H. Chen, Y.-P. Lin

The paper shows that antibodies targeting CspZ FH-binding sites effectively clear Lyme borreliae in vitro and in vivo, highlighting their importance for vaccine development.

bioRxiv · May 24, 2022Immunology

Host specialization in microparasites transmitted by generalist vectors: insights into the cellular and immunological mechanisms

Y.-P. Lin, D. M. Tufts, A. P. Dupuis, M. Combs, A. L. Marcinkiewicz, A. D. Hirsbrunner, A. J. Diaz, J. L. Stout, A. M. Blom, K. Strle, A. D. Davis, L. D. Kramer, M. A. Diuk-Wasser

This study investigates host specialization in Lyme disease bacteria by testing different genotypes in reservoir hosts, finding that bacterial persistence depends on adhesion and immune evasion traits.

bioRxiv · Nov 13, 2020 · PreprintMicrobiology