K. Strle

HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis

This paper shows that HLA-DR-expressing fibroblast-like synoviocytes can present Lyme autoantigens and activate CD4+ T cells when stimulated with IFN-gamma and Borrelia burgdorferi.

Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research

The paper constructs a proteome resource, Borrelia PeptideAtlas, by integrating transcriptomic and proteomic data from multiple B. burgdorferi isolates to identify common proteins across infective strains.

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

Phylogenomic diversity elucidates mechanistic insights into Lyme borreliae host association

This study investigates how genetic variation in Lyme disease-causing Borrelia burgdorferi strains relates to their ability to evade host complement immune responses, revealing host-specific complement-evasion phenotypes.

Host specialization in microparasites transmitted by generalist vectors: insights into the cellular and immunological mechanisms

This study investigates host specialization in Lyme disease bacteria by testing different genotypes in reservoir hosts, finding that bacterial persistence depends on adhesion and immune evasion traits.