Author

L. D. Kramer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. M. Blom· 2 shared A. P. Dupuis· 2 shared D. M. Tufts· 2 shared M. A. Diuk-Wasser· 2 shared Y.-P. Lin· 2 shared A. D. Davis· 1 shared A. D. Hirsbrunner· 1 shared A. J. Diaz· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

A. M. Blom

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid

A. J. Friedman, E. T. Liechty, L. D. Kramer, A. Sarkar, J. Fox, M. Shirts

This study identifies amorphadiene as a selective allosteric inhibitor of PTP1B, showing it binds to multiple sites on the C-terminus and stabilizes the PTP1B-AD complex.

bioRxiv · May 18, 2022Biochemistry

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

T. M. Hart, A. P. Dupuis, D. M. Tufts, A. M. Blom, S. Starkey, R. O. M. Rego, S. Ram, P. Kraiczy, L. D. Kramer, M. A. Diuk-Wasser, S.-O. Kolokotronis, Y.-P. Lin

The paper identifies CspA as a determinant of host tropism in Lyme disease bacteria, showing convergent evolution drives transmission differences among vertebrates.

bioRxiv · Feb 9, 2021Microbiology

Host specialization in microparasites transmitted by generalist vectors: insights into the cellular and immunological mechanisms

Y.-P. Lin, D. M. Tufts, A. P. Dupuis, M. Combs, A. L. Marcinkiewicz, A. D. Hirsbrunner, A. J. Diaz, J. L. Stout, A. M. Blom, K. Strle, A. D. Davis, L. D. Kramer, M. A. Diuk-Wasser

This study investigates host specialization in Lyme disease bacteria by testing different genotypes in reservoir hosts, finding that bacterial persistence depends on adhesion and immune evasion traits.

bioRxiv · Nov 13, 2020 · PreprintMicrobiology

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

P. S. Kwon, S. Ren, S.-J. Kwon, M. E. Kizer, L. Kuo, F. Zhou, F. Zhang, D. Kim, K. Fraser, L. D. Kramer, N. C. Seeman, J. S. Dordick, R. J. Linhardt, J. Chao, X. Wang

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

bioRxiv · Apr 13, 2019Bioengineering