Author

A. L. Patchett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. B. Lyons· 3 shared A. S. Flies· 3 shared J. M. Darby· 3 shared C. E. B. Ong· 2 shared G. M. Woods· 2 shared G.-S. Liu· 2 shared A. N. Kayigwe· 1 shared J. Chen· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

A. B. Lyons

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I

A. N. Kayigwe, J. M. Darby, A. B. Lyons, A. L. Patchett, L. Lisowski, G.-S. Liu, A. S. Flies

This study shows a human adenovirus encoding IFN-γ can upregulate MHC-I in Tasmanian devil tumor cells, suggesting its potential as a vaccine platform.

bioRxiv · May 29, 2022Immunology

NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

C. E. B. Ong, A. L. Patchett, J. M. Darby, J. Chen, G.-S. Liu, A. B. Lyons, G. M. Woods, A. S. Flies

This study shows NLRC5 upregulates MHC-I in transmissible cancers, making MHC-I a target for anti-tumor immunity and informing immunotherapy strategies.

bioRxiv · Sep 6, 2020Immunology

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

A. S. Flies, J. M. Darby, P. R. Lennard, P. R. Murphy, C. E. B. Ong, T. L. Pinfold, A. B. Lyons, G. M. Woods, A. L. Patchett

The paper develops a reagent method to study immune checkpoints in non-model species and identifies conserved immune evasion pathways in transmissible cancers.

bioRxiv · Jan 3, 2020Immunology