Author

A. B. Lyons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Organism:non-human primate· 2

Frequent Co-Authors

G. M. Woods· 6 shared A. S. Flies· 5 shared J. M. Darby· 4 shared A. L. Patchett· 3 shared C. E. B. Ong· 3 shared C. Espejo· 2 shared E. Willms· 2 shared G.-S. Liu· 2 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersImmunology

G. M. Woods

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I

A. N. Kayigwe, J. M. Darby, A. B. Lyons, A. L. Patchett, L. Lisowski, G.-S. Liu, A. S. Flies

This study shows a human adenovirus encoding IFN-γ can upregulate MHC-I in Tasmanian devil tumor cells, suggesting its potential as a vaccine platform.

bioRxiv · May 29, 2022Immunology

Cathelicidin-3 associated with serum extracellular vesicles enables early diagnosis of a transmissible cancer

C. Espejo, R. Wilson, R. J. Pye, J. C. Ratcliffe, M. Ruiz-Aravena, E. Willms, B. W. Wolfe, R. Hamede, A. F. Hill, M. E. Jones, G. M. Woods, A. B. Lyons

The paper identifies cathelicidin-3 in serum extracellular vesicles as a biomarker for early diagnosis of DFTD in Tasmanian devils with high sensitivity and specificity.

bioRxiv · Dec 6, 2021Cancer Biology

CIITA induces expression of MHC-I and MHC-II in transmissible cancers

C. E. B. Ong, Y. Cheng, H. Siddle, A. B. Lyons, G. M. Woods, A. S. Flies

This paper shows that CIITA upregulates MHC-I and MHC-II in transmissible cancers, with differential protein expression and functional implications for immune evasion.

bioRxiv · Jul 14, 2021 · PreprintImmunology

Post release immune responses of Tasmanian devils vaccinated with an experimental devil facial tumour disease vaccine

R. Pye, J. Darby, A. Flies, S. Fox, S. Carver, J. Elmer, K. Swift, C. Hogg, D. Pemberton, G. Woods, A. B. Lyons

This study evaluates the immune response of Tasmanian devils vaccinated against DFTD, finding persistent antibodies and immune cell infiltration in tumors, but no complete protection against DFTD development.

bioRxiv · Dec 6, 2020Immunology

Tasmanian devil facial tumour-derived extracellular vesicles reveal mesenchymal transition markers and adhesion molecules related to metastasis.

C. Espejo, R. Wilson, G. M. Woods, E. Willms, A. Hill, A. B. Lyons

This study analyzes extracellular vesicles from Tasmanian devil cancers to identify markers of metastasis and differential aggressiveness between two cancer types.

bioRxiv · Oct 18, 2020 · PreprintCancer Biology

NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

C. E. B. Ong, A. L. Patchett, J. M. Darby, J. Chen, G.-S. Liu, A. B. Lyons, G. M. Woods, A. S. Flies

This study shows NLRC5 upregulates MHC-I in transmissible cancers, making MHC-I a target for anti-tumor immunity and informing immunotherapy strategies.

bioRxiv · Sep 6, 2020Immunology

Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells

C. Wong, J. M. Darby, P. R. Murphy, T. L. Pinfold, P. R. Lennard, G. M. Woods, A. B. Lyons, A. S. Flies

This study shows Tasmanian devil CTLA4 and CD28 can capture CD80 and CD86 from adjacent cells, similar to other species, suggesting potential for checkpoint immunotherapy in divergent species.

bioRxiv · Jun 11, 2020Immunology

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

A. S. Flies, J. M. Darby, P. R. Lennard, P. R. Murphy, C. E. B. Ong, T. L. Pinfold, A. B. Lyons, G. M. Woods, A. L. Patchett

The paper develops a reagent method to study immune checkpoints in non-model species and identifies conserved immune evasion pathways in transmissible cancers.

bioRxiv · Jan 3, 2020Immunology