Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
B. Slyp, J. M. Darby, A. S. Flies
This paper converts mouse-derived hybridoma antibodies into Tasmanian devil recombinant IgG antibodies for use in functional assays and immunotherapy.
A. N. Kayigwe, J. M. Darby, A. B. Lyons…·A. S. Flies
This study shows a human adenovirus encoding IFN-γ can upregulate MHC-I in Tasmanian devil tumor cells, suggesting its potential as a vaccine platform.
C. E. B. Ong, A. L. Patchett, J. M. Darby…·A. S. Flies
This study shows NLRC5 upregulates MHC-I in transmissible cancers, making MHC-I a target for anti-tumor immunity and informing immunotherapy strategies.
C. Wong, J. M. Darby, P. R. Murphy…·A. S. Flies
This study shows Tasmanian devil CTLA4 and CD28 can capture CD80 and CD86 from adjacent cells, similar to other species, suggesting potential for checkpoint immunotherapy in divergent species.
A. S. Flies, J. M. Darby, P. R. Lennard…·A. L. Patchett
The paper develops a reagent method to study immune checkpoints in non-model species and identifies conserved immune evasion pathways in transmissible cancers.