Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors
J. A. Grout, P. Sirven, A. M. Leader, S. Maskey, E. Hector, I. Puisieux, F. Steffan, E. Cheng, N. Tung, M. Maurin, R. Vaineau, L. Karpf, M. Plaud, M. Casanova-Acebes, A. Tabachnikova, , H. Salmon
The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.
bioRxiv · Jan 20, 2022Cancer Biology